Dosing and administration
ISEMBYLD (10 mg/kg) is administered intravenously every 4 weeks, with weight-based dosing1
Reference:
1. ISEMBYLD. Prescribing information. Scholar Rock, Inc; 2026.
ISEMBYLD is administered by a healthcare professional in a hospital, at home, or at an infusion center1
The intravenous (IV) infusion is given over approximately 1 to 2 hours at an infusion rate no greater than 150 mL/hour.
ISEMBYLD must be diluted prior to administration.
If a planned dose is missed, it is recommended to administer ISEMBYLD as soon as possible and then restart the dosing schedule 4 weeks after the missed dose is administered.1
Alternatively, if a planned dose is missed, dosing may be resumed on the next scheduled dose to maintain the original dosing schedule.
Reference:
1. ISEMBYLD. Prescribing information. Scholar Rock, Inc; 2026.
ISEMBYLD Dosing Calculator1
The recommended dosage of ISEMBYLD is 10 mg/kg administered once every 4 weeks as an intravenous infusion over approximately 60 minutes to 120 minutes at an infusion rate no greater than 150 mL/hour. Vials are single-dose only. Unused ISEMBYLD should be discarded. Dose calculations based on 10 mg/kg.
Total Dose
mg
Total Vials Needed
vials
Total Volume to Withdraw
mL
Total Saline Volume
mL
Total Infusion Volume
mL
Administration instructions
Full Prescribing Information- If necessary, remove the diluted ISEMBYLD solution from the refrigerator and allow the diluted solution to warm to room temperature. Do not use external heat sources to warm ISEMBYLD diluted solution because heat may damage the product.
- Visually inspect the diluted ISEMBYLD solution for particles or discoloration prior to administration [see Dosage Forms and Strengths (3)]. Do not use if it is discolored, opaque, or foreign particles are seen.
- Use a dedicated line with an infusion set containing a 0.2 or 0.22 micron low protein binding polyethersulfone (PES) in-line infusion filter. Use infusion sets and lines that are di(2-ethylhexyl)phthalate (DEHP)-free.
- Infuse the diluted solution of ISEMBYLD intravenously over approximately 60 minutes to 120 minutes at an infusion rate no greater than 150 mL/hour.
- After completion of the infusion, flush the infusion line with 0.9% Sodium Chloride Injection to ensure that all the ISEMBYLD has been administered.
- If a planned dose is missed, it is recommended to administer ISEMBYLD as soon as possible and then restart the dosing schedule 4 weeks after the missed dose is administered.
- Alternatively, if a planned dose is missed, dosing may be resumed on the next scheduled dose to maintain the original dosing schedule.
Total Dose
Weight (kg) x Recommended dose (10 mg/kg)
Total Vials Needed
Total dose (mg) ÷ Amount of 1 vial (150 mg)
Total Volume to Withdraw
Total dose (mg) ÷ 50 mg/mL
Each mL contains 50 mg
Total Saline Volume
Total infusion volume (mL) – Total volume to withdraw (mL)
Total Infusion Volume
Total dose (mg) ÷ 5 mg/mL
Disclaimer: By using this dosing calculator, you agree to the following: This dosing calculator is intended for use by qualified healthcare providers only. The information provided is not a substitute for clinical judgment. Scholar Rock, Inc. makes no claims as to the accuracy of the information provided. All calculations should be confirmed prior to administration. Neither Scholar Rock, Inc. nor any party involved in the creation or publication of this website shall be liable to you or others for any actions taken or decisions made in reliance on the information provided by this dosing calculator. Please refer to the ISEMBYLD full Prescribing Information, which contains complete dosing and administration information.
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RELATED FAQs
How is ISEMBYLD administered, and where?
ISEMBYLD (10 mg/kg) is administered intravenously every 4 weeks, with weight-based dosing, by a healthcare professional in a hospital, at home, or at an infusion center. The intravenous (IV) infusion is given over approximately 1 to 2 hours at an infusion rate no greater than 150 mL/hour. ISEMBYLD must be diluted prior to administration.1
What happens if a dose is missed?
If a planned dose is missed, it is recommended to administer ISEMBYLD as soon as possible and then restart the dosing schedule 4 weeks after the missed dose is administered. Alternatively, if a planned dose is missed, dosing may be resumed on the next scheduled dose to maintain the original dosing schedule.1
References:
1. ISEMBYLD. Prescribing information. Scholar Rock, Inc; 2026.